摘要
报道了联苯胺接触者及其膀胱癌患者和正常对照者淋巴细胞染色体畸变和膀胱癌发病的关系。观察对象包括三组,A组为联苯胺接触者发生膀胱癌的病人(15例)B组为联苯胺接触者(15人),C组为正常对照工人(14人)。三组中淋巴细胞畸变的人数分别占60.0%,58.3%及14.0%,其淋巴细胞畸变率分别为1.1%,0.7%及0.3%。A、B组显著高于C组,且膀胱癌组比非膀胱癌组细胞畸变率高。A组有4例发现有2个以上的淋巴细胞畸变,B组仅有2例,其中1例在染色体畸变检验后1年发生了膀胱癌。对有染色体畸变者作G带分析的结果表明主要是缺失、易位、断裂和插入,其中多数在9号、8号、6号染色体,且A组至少牵涉3次。表明具有较高畸变的个体可能有较高的膀胱癌危险性。外周血淋巴细胞染色体畸变及/或先天的遗传缺陷(通称为染色体不稳定性)反映了癌症的易感性。作者认为联苯胺工人淋巴细胞染色体畸变率增高可与其它生物学标记相结合作为膀胱癌早期监测的指标。
This study reported the relationship of chromosome aberration with prevalence of bladder cancer in workers exposed to benzidine with or without bladder cancer.The subjects were divided into three groups.Group A: 15 cases with bladder cancer exposed to benzidine;group B:15 workers exposed to benzidine ;group C:14 healthy individuals. There were 60, 58 and 14%individuals with chromosome aberration in group A,B and C respectively. The lymphocyte aberration rates were 1.1,0.7 and 0.3%respectively. They were statistical1y significant1y With chromosome aberration higher in group A and B than in group C.The rate of cell aberrantion was higher in group A than in group B.There are 4 individuals with more than 2 aberrant cells in group A and 2 individuals in group B. In group B one worker who had chromosome structure oberration developed bladder cancer one year later.In chromosome G-band analysis, most aberrations occurred on chromosomes # 9,#8and#6 with deletion, transloeation insert or break.This study may demonstrate that the individuals with higher frequency of aberrant cell have higher risk of bladder cancer.Chromosome aberration and deficiency in predisposition represent chromosome instability.The authors suggest that the chromosome aberrant rate in lymphocyte of workers exposed to benzidine could be an early biomarker for bladder cancer caused by exposure to benzidine.
出处
《卫生研究》
CAS
CSCD
北大核心
1995年第6期324-327,共4页
Journal of Hygiene Research
关键词
联苯胺
膀胱肿瘤
染色体畸变
benzidine
bladder cancer
chromosome aberration
G-and