碳酸锂抗诱变作用的研究

Studies on antimutagenic effect of lithium caroonate

本研究首次用体外培养人胚纤维母细胞（ＨＥＦ）和活体小鼠骨髓嗜多染红细胞（ＰＣＥ）两种生物系统，选择四种不同性质的诱变剂（ＵＶ、ＮＨ２ＨＣｌ、ＮａＡｓＯ２、ＣＰ）诱导三种不同效应水平（ＵＤＳ、ＣＡ、ＭＮ）的诱变模型，并采用受试物多种处理方式，从遗传学角度综合评估了碳酸锂的抗诱变作用。结果表明碳酸锂本身未见诱变活性。在多种水平的抗诱变试验终点中，明确显示了诱变抑制作用，可能有使用价值。

Antimutagenic effect of Li2co3 has been evaluated by means of unscheduled DNA synthesis(UDS) test,chromosomal aberration(CA) test in vitro human embryofibroblast(HEF)and micronuclus(MN) test in mouse bone marrow polychromatic erythrocyte(PCE) inducing by four different properties mutagenes,i.e.,short wave ultraviolet(UV),hydrochloric acid nitrogen mustard(NH2HCl),Arsenic sodium oxide(NaAsO2) and cyclophosphamide(CP).The results of this study indicated:Li2CO3 has not mutagenic effect.The effects of antimutagenic of Li2CO3 is obvious in multiple antimutagenic system Li2CO3 may useful in prevention of human cancer.