自身免疫性溶血性贫血自身抗体血型特异性的鉴定及其临床意义

The Identification of Blood Group Specificity of Autoantibody in Patients with Autoimmune Hemolytic Anemia

本文采用乙醚放散法,以O型R_1R_1,R_2R_2和rr为试剂红细胞,鉴定了16例自身免疫性溶血性贫血患者自身抗体的血型特异性,结果发现4例自身抗体具有血型抗原特异性,其中抗-E1例,抗-C1例,抗-e2例,为其选择相合的血液输注,避免了输血反应.进行自身抗体血型特异性的鉴定,是防止医源性溶血的有力措施.

The blood group specificity of autoantibodies in 16 patients with autoimmune hemolytic anemia (AI-HA) was identified by ether elution with O, R_1R_1, R_2R_2 and rr reagent red blood cells. The autoantibodies with blood group specificity were found in 4 cases, of them, one was of anti-E, one of anti-C and two of anti-e. These patients were transfused with compatible blood without transfusion reactions. To identify the specificity of patient's autoantibodies is one of effective approaches to prevent iatrogenic hemolytic reactions.