尿中肌酐排泄稳定性的研究

Study on the stability of creatinine excretion in urine

分析在自由饮水条件下７７３个健康人的一次点尿样，６２人的２４ｈ尿样及８人连续５天收集的２４ｈ尿样，对这些尿样分别测定比重、肌酐浓度及肌酐排泄量，以揭示尿肌酐排泄的稳定性。研究发现，尿肌酐浓度与尿比重之间具有一定的相关性，尿肌酐排泄存在明显的个性差异和体内变异。可以认为，肌酐排泄的稳定性较差，用肌酐作为尿毒物浓度的校正参数，其适合性和可靠性值得怀疑。

In order to reveal the stability of urinary creatinine excretion,urinary specific gravity,creatinine concentration and creatinine exeretion amount were measured for spot urine samples from 773 subjects,24h urine samples collected from 62 volunteers,and 24 h urine samples collected from 8 volunteers for five consecutive days under free fluid intake.It was found that there was a slight correlation between urinary creatinine concentrations and specific gravity of urine.Inter-and intra-individual variations in urinary creatinine excretion were great.It is concluded that creatinine excretion in urine is not stable and,theretore,the validity and reliability of creatinine as a reference used to adjust the toxic substances excreted in urine are not reliable.