氟化钠对大鼠实验性骨质疏松症预防作用的研究

Preventive effecets of sodium fluoride on experimental osteopcrosis in rats

本研究选用健康成年的ＳＤ大鼠４２只，随机分为６组，于大鼠饮用水中加入不同剂量的氟化钠，饮４周后，维甲酸灌胃２周，诱发大鼠实验性骨质疏松症模型，实验期共６周。通过对大鼠血液和骨骼氟（Ｆ）、钙（Ｃａ）、磷（Ｐ）、羟脯氨酸（ＨＯＰ）测定以及骨组织形态学等指标的分析，结果表明：（１）氟化钠可以预防或减轻由维甲酸引起的大鼠骨质疏松症；（２）达到预防效果的最佳水氟浓度范围是１０～２０ｍｇ／Ｌ；（３）对于预防人类骨质疏松症，氟的有效剂量和时间尚需做进一步的探讨。

Forty two rats were divided into 6 groups randomly to study the preventive effects of sodium fluoride on experimental osteoporosis.Rats drank fluoridated water containing various dosages of sodium fluoride for 4 weeks.The rats were then administered by gavage with retinoic acid for 2 weeks to induce experimental osteoporosis model,fluoridated water was given simuetaneousey,Two weeks eater the contents of fluorine,calcium,phosphorus and hydroxyproline in blood and bone were meosured and femoral histomorphology observed.(1)Sodium fluoride may prevent osteoporosis in rats induced by retinoic acid.(2) The most suitable fluorine ion concentration in fluoridated water is 10～20g/L.(3) The effective fluoride dosage and the most suitable period taking fluoride remain to be studied deeply,when fluoride is taken to prevent human osteoporosis.