细脚拟青霉对小鼠血清及肝、脾、肾组织酸性磷酸酶活力的影响

EFFECTS OF PAECILOMYCES TENUIPES ON THE ACTIVITY OF ACID PHOSPHATASE IN SERUM,LIVER,SPLEEN AND KIDNEY OF MICE

本文观察了细脚拟青霉菌丝体水煎剂对正常及环磷酰胺所致免疫抑制小鼠血清及肝、脾、肾组织中酸性磷酸酶活力的影响作用。结果表明：细脚拟青霉水煎剂给小鼠灌胃２１天后，小鼠血清中酸性磷酸酶活力无显著改变，正常小鼠脾组织酸性磷酸酶活力显著提高，对环磷酰胺所致小鼠肝、脾、肾组织酸性磷酸酶活力下降具有非常显著的抑制作用。提示：细脚拟青霉对免疫抑制小鼠脏器组织内的酸性磷酸酶活力具有调节作用。

he effects of Paecilomyces tenuipes aqueous decoction on the activity of acid phosphatase( AC-Pase) in the serum , liver , spleen and kidney of the normal mice and immunosuppressed mice inducedby cyclophosphamide were observed. The results indicated that after the aqueous decoction of Pae-cilomyces tenuipes was perfused into the stomach for 2l days, the activity of ACPasein the serum ofmice had no marked changes. The activity of ACPase in the spleen of normal mice increased marked-ly, and the decrease of the activity of ACPase in the liver, spleen, kidney. of immunosuppressed miceinduced by cyclophosphamide was inhibited greatly. It is suggested that Paecilomyces tenuipes couldregulate the activity of ACPase in the organs of the immunpsuppressed mice.