再生障碍性贫血自然杀伤细胞的量及活性研究

STUDY ON NATURAL KILLER AC TIVIY AND NATURAL KILLER CELL COUNT IN PATIENTS WITH APLASTIC ANEMIA

对２０例再障患者周围血的自然杀伤细胞（ＮＫ细胞）量及活性进行了研究。发现再障患者的ＮＫ细胞活性（Ｋ５６２）及量（ＣＤ１６阳性细胞）与正常人相比减少均有非常显著意义（Ｐ＜０．０１）。同时对５例短期内缓解的患者作了动态观察，发现随病情的改善ＮＫ细胞活性和量逐渐提高。提示再障患者存在ＮＫ细胞的损伤并与病情发展成正相关。

wenty patients with aplastic anemia were studied with regard to NK activity(K562)and NKcell.(CD16+cell)count in the peripheral blcod. NK activity and NK cell count were significantly de-creased(P<0.01)in the patients compared to healthy control subjects. Meanwhiie five patients whohad remitted in a short period were dynamically observed. It showed that NK cell count and NK activi-ty were gradually increased with the patient condition improving progressively. These results suggest-ed that NK eell have been impaired in the patients with aplastic anemia and the degree of impairmentbe positively correlated with the development of patient conditions.