N－甲基咪唑与氯高铁血红素取代反应动力学

KINETIC STUDY OF NUCLEOPHILIC SUBSTITUTION REACTIONS OF N-METHYLIMIDAZOLE WITH HEMIN CHLORIDE

本文用停流法和分光光度法研究了［Ｆｅ（ｐｏｒ）Ｃｌ］（ｐｏｒ＝原卟啉（ｐｐ）或对应的二甲酯（ｐｐｄｍｅ））与Ｎ－甲基咪唑（Ｎ—ＭｅＩｍ）的亲核取代反应动力学，讨论了反应机理，求得前置平衡的平衡常数（Ｋ）和基元步骤的速率常数（ｋ１），研究了温度对反应动力学的影响。

Kinetics of the nucleophilic substitution reaction (1 ) of N-methylimidazolc (N-MeIm) with bemin chloride [Fe(por)Cl] (por=dianion of protoporphyrin IX (pp) or the corresponding dimethyl ester (ppdme)) to give [Fe(por)(N-MeIm)2]+Cl- was of Stppped-flow and Visible speetroseopic.The proposed mechanism is as follows:The equilibrium constants (K) and rate constants (k1) were botanied. The standard molecular cnthalpy change and standard cntropy chance of step one and activation parameters were calculated.