特发性血小板减少性紫癜患儿外周血T_（48）^（＋＋）双标记细胞的分布

Distribution of T_(48)^(++) double-labelled cells in peripheral blood 30 children with idiopathic thrombocytopenic purpura

用减数法观察了３０例原发性血小板减少性紫癜（ＩＴＰ）患儿外周血Ｔ双标记细胞（ＤＬＣ）的分布及ＤＬＣ分别与血小板计数（ＰＣ）、血小板表面相关抗体ＩｇＧ（ＰＡＩｇＧ）、ＨＬＡ－ＤＲ＋Ｔ细胞及ＨＬＡ─ＤＱ＋Ｔ细胞的关系。发现：ＩＴＰ患儿的ＤＬＣ较正常对照组显著升高（Ｐ＜０．０１）。ＤＬＣ与ＰＡＩｇＧ、ＨＬＡ─ＤＲ＋Ｔ及ＨＬＡ─ＤＱ＋Ｔ均呈显著正相关（Ｐ分别＜０．０５、０．０５及０．０１），与ＰＣ呈负相关（Ｐ＜０．０５）。提示ＤＬＣ在外周血中的大量出现与ＩＴＰ发病密切相关。

The distribution of T_4￣+￣ 8￣+ double-labelled cells (DLC) in peripheral blood in 30 children with idiopathic thrombocytopenic purpura(ITP) was observed by subtraction method , and the correlations of DLC with platelet counts, platelet-associated IgG HLA-DR+ T cells,and HLA-DQ+ T cells were analysed. The results showed a marked increase of DLC in children with ITP compared with normal children(P<0. 01);the correlations of DLC with platelet-associated IgG,HLA-DR+ T cells and HLA-DR+ T cells were positive (P<0. 05, 0. 05 and 0.01,respectively) while that of DLC with platelet counts was negtive(P<0. 05). It is indicated that the increase of DLC in peripheral blood may play an important role in the pathogenenesis of ITP.