急性重复缺氧海马锥体层神经元光镜观察

Observation of CA1 pyramidal cell layer of acute repetitive hypoxia in mouse hippocampus

为探讨急性重复缺氧动物对缺氧耐受性增加的形态学基础，对５２只昆明小鼠海马ＣＡ１区锥体层神经元作光镜观察。结果：①肥大神经元在１次、３次、５次缺氧组均存在。②萎缩神经元在１次缺氧组存活７ｄ、３次缺氧组存活３ｄ、５次缺氧组存活１ｄ时才出现。③固缩神经元在１次缺氧组未出现，在３次缺氧组存活７ｄ、５次缺氧组存活３ｄ时才出现。认为肥大神经元是其形态学基础之一，萎缩神经元是适应性变化之一，固缩神经元是迟发性神经元坏死变化之一。

In order to study morphological basis of tolerance for acute repetitive hypoxia, the CA1 pyramidal neurons of mouse hippocampus were observed by light microscopy. The results showed that there were hypertrophic neurons in groups receiving 1, 3 and 5 times of hypoxia. Atrophic neurons appeared after 7 days, 3 days and 1 day in the groups receiving 1, 3, and 5 times of hypoxia ,respectively. It is indicated that the hypertrophy of neurons is one of morphological alterations ,the atrophy of neurons is an adaptive change and the pyknosis of neurons is delayed neuron death when acute repetitive hypoxia occurs in mice.