比较分子场分析研究哒嗪酮等体系的三维构效关系

Comparative Molecular Field Analysis of Inotropic Compounds and Pyridazinone

用比较分子场分析（CoMFA）法对两个体系的化合物进行了研究，得到了预报能力较强的模型.初步的研究表明，作为一种三维定量构效（3D-QSAR）方法，它能够揭示分子三维结构对活性的贡献，有较广阔的应用前景．

A series of 19 steroids of pyrazione and 37 steroids of inotropic compounds has been studied using CoMFA method. Three-dimension quantitative structure-activity relation is obtained to predict the activity of unknown compounds.