拉萨藏族血清脂肪酸及胆固醇与血压的关系

The relationship among serum fatty acids cholesterol and the level of blood pressure in Tibetan population of Lhasa

对49—54岁年龄组的拉萨藏族98（男42、女56）例的血清TC、TP、ALB、Na、K及FA（N＝12，男14，女56）等变量作了测定，以探讨血脂质及脂肪酸与血压水平的关系。结果显示：血清亚油酸、C：20—3、ω－3族等脂肪酸含量较低、C：14－0与SBP、DBP呈显著正相关；TC、C：20－3、C：20－4及20－5与SBP或DBP呈显著负相关。C：14－0及C：16－1cis作为正性因子进入SBP及DBP多元回归方程；TC、C：24－1、C：20－2、C：20－3及20－5作为负性因子进入SBP及DBP多元回归方程。高血压组SBP变异可能41％归因于C：14－0、DBP变异可能45％归因于C：20－3。结果提示饮食中饱和脂肪酸C：14－0过多以及某些多不饱和脂肪酸如C：20－3，ω－3族不足是引起拉萨藏族人群平均血压和患病率高的因素。而摄取动物性脂肪过多、植物性食油和鱼类食物较少可能是导致上述饮食中营养成分结构失调的原因。

Ninty eighy (42male 56female)Tibetans agcd in 49 -54 group were selected randomly for BP. serum cholesterol (TC). total protein, alburnin Na, k and fatty acide (FA) (N=42, 14 male 28 female) measurernents in Lhasa to assess the relationship among serum FA, TC variables and BP. The results showed that the level of C:18-2, C: 20-3. and w-3 were lower. TC was not higher as would be expected and was lower in the hypertensive subjects as compared with the normotensive subjects the C:10 at-0was much positively correlated with SBP or DBP;TC,C: 20-3,C: 20-4 and C: 20-5 were much inversely corrclated with SBP or DBP. C: 14-0 and C:16-1cis were positive in the SBP or DBP multiple regression equation: TC,C: 24-1, C: 20 2, C: 20-3, and C: 2 - 5 were inverse in the multipIe regrssion equation ln the hypertensive subjects C: 14-0 was in the regression with 41% of variance explained,and C: 2-3 was in the regression with 45% of variance explained.It suggested that C: 14-0 being higher and some unsaturated FA such as C: 20-3, w-3 being lower in the diets may be responsible for the higher prevalence rates of hypertension in Lhasa. Further more animal fat intake and lack of plant oil and fish in diets rnay result in proportional imbelance of nutrtional constituents.