心肌梗塞大鼠心室胶原基质生化改建的研究

EXPERIMENT STUDY ON THE BIOCHEMICAL BEMODELING VENTRICULAR COLLAGEN MATRIX FOLLOWING MYOCARDIAL INFARCTION IN RATS

采用大鼠心肌梗塞（ＭＩ）模型动态观察了ＭＩ后３、１５及４２ｄ心室各部位胶原含量、总量及Ⅰ、Ⅲ型胶原蛋白比值（Ⅰ／Ⅲ）的变化。结果表明：左室非梗塞区（ＮＩＡ）和右室（ＲＶ）的胶原总量均随心肌肥大的发展而进行性增加，但两者胶原含量的变化表现不同，ＲＶ胶原含量无明显的改变，而ＮＩＡ呈双相变化；梗塞区（ＩＡ）胶原含量则随修复过程而迅速增加。ＭＩ早期ＮＩＡ以Ⅲ型增加为主，中后期ＮＩＡ及ＲＶ肥大心肌中均以Ⅰ型增加为主，ＩＡⅠ／Ⅲ呈现出与ＮＩＡ相反的动态改变。

The present study was performed to characterize the biochemical remodeling of ventricular collagen matrix and its natural history following myocardial infarction (MI)in rats. Collagen concentration, the total collagen content and the ratio of type Ⅰ∶Ⅲ collagen (Ⅰ/Ⅲ) were measured on days 3,15 and 42. The results showed :①The total collagen content of non-infarcted area (NIA) and right ventricle (RV)following the development of ventricular hypertrophy increased progressively. Although the collagen concentration had no difference in RV, it showed dynamic changes in NIA. Both the collagen concentration and the total collagen content in infarcted area (IA)increased rapidly following reparative fibrosis. ② At the early stage of MI, tyep Ⅲ collagen in NIA increased significantly; later, type Ⅰ collagen was remarkedly higher in NIAand RV. In IA Ⅰ/Ⅲ showed different patterns than that of NIA.