肺康宝对小儿反复呼吸道感染免疫调节作用的临床及实验研究

CLINICAL AND LABORATORIAL OBSERVATION ON IMMUNE REGULATION REACTION IN CHILDREN WITH REPEAT RESPIRATORY INFECTION TREATED WITH FEIKANGBAO

本文检测了116例反复呼吸道感染(RRI)患儿的T淋巴细胞及其亚群、淋巴细胞转化率(LTT)、E玫瑰花结形成率(E—RFR)及血清免疫球蛋白,结果发现83％患儿存在明显的免疫功能低下,表明免疫功能失调是导致RRI的重要原因之一。在用中药肺康宝口服液后,CD_3、CD_4、CD_8阳性细胞数、LTT、E—RFR、IgA水平较治疗前均有显著提高(P<0.001);临床显效72.4％,进步25％,总有效率97.4％。药效学试验表明:肺康宝口服液能明显增强机体细胞免疫及体液免疫功能,并具有镇咳、耐疲劳、耐缺氧及抗过敏作用。

The 116 cases of children with repeat respiratory infection (RRI) were observed in this paper. RRI was closely related to respiratory syncytial virus in infantil and young children lower respiratory infection. Simultaneously, T lymphocyte and it's subtypes. LTT, ERFR and serum immunoglobulins were examined. The results showed that there was different degree hypoimmunity in 83% cases, and that it was one of the important reasons that im-munological derangement caused RRI, and that CD3, CD4, CD8, LTT, ERFR and IgA were obviously in-creased (P < 0.001) after the children with RRI were treated with traditional chinese medicine Feikangbao(肺康宝) and that also there were very effective improvements on clinical manifestations in 72.4% cases, effective in 25%, total effective rate 97.4%. In addition, stuty of Feikangbao's pharmacological laboratory indicated that it not only improved cellular immune and humoral immune function , but also had antibechic fatigue tolerence, anoxia tolerence and antianaphylaxis function.