胃癌细胞内微囊超微结构的研究

ULTRASTRUCTURE OF MICROCYSTS OF GASTRIC CARCINOMA AND ITS DIAGNOSTIC SIGNIFICANCE

本文通过一组胃癌病例描述了细胞内微囊的超微结构及其诊断意义。全组75例胃癌中17例在癌细胞中发现微囊。电镜下,微囊乃细胞浆内的一种特殊结构,为与外界不相通的孤立囊腔,内表面披以微绒毛,囊腔内含有低电子密度的颗粒状物质。关于微囊的组织来源,作者推测可能来自二级溶酶体。由于微囊常见于胃癌而在其他癌瘤中罕见,故对胃癌的诊断具有一定的意义。

This paper describes the ultrastructure of microcysts in a seriesof gastric carcinoma with reference to its diagnosis significance.Of the seventy-five cases, thirteen have been found to have microcysts in cancer cells, Ultrastructural-ly, microcyst is a specific structure within the cytoplasm, it is an isolated cyto-plasmic cyst with microvilli in its inner surface, this microcyst contains electron-lecent granular material. As to the histogenesis of microcyst, the author suggests that it might derive from the secondary lysosomes. Because of its frequent occurrence in gastric cancer and rare appearance in other types of tumor, it is of significance in the diagnosis of gastric cancer.