用多聚酶链反应探讨单纯疱疹病毒感染与宫颈疾病的关系

Detection of herpes simplex virus infection in cervical samplers by polymerase chain reaction.

使用多聚酶链反应（ＰＣＲ）探讨了单纯疱疹病毒感染与慢性宫颈炎，宫颈癌的关系。结果表明，在３１份正常妇女，７２份慢性宫颈炎、２１份宫颈癌标本中检出ＨＳＶ阳性分别为４份（１３．３％）、２５份（３４．７％）和１２份（５７．１％），阳性率呈明显升高的趋势；在慢性宫颈炎患者中，随宫颈糜烂程度的增加，ＨＳＶ感染率升高。提示ＨＳＶ感染与慢性宫颈炎、宫颈癌的发生、发展相关；ＰＣＲ是检测ＨＳＶ感染灵敏、简便的方法。

Polymerase chain reaction was applied to detect herpes simplex virus infection in cervical samplers .In 31 rormal women, 72 cases with chronic cervicitis, 21 cases with cervical cancer, 4, 25 and 12 ones were HSV-positive respectively, showing remarkably increasing in positive rates.In patients with chronic cervicitis,the infective rate of HSV ran in parallel with the increase in the degree of cervical erosion. The results indicate that HSV infection is associated with the occuration of chronic cervicitis and cervical cancer, and PCR is a sensitive and simple method to detect HSV infection.