^（32）P－玻璃微球子宫动脉灌注治疗宫颈癌的初步研究

Intra-arterial radiation therapy of phosphorus-32 glass microspkeresfor cervieal carcinoma

对６例中晚期外生型子宫颈癌患者行腹膜外盆腔淋巴结清扫术加子宫动脉３２Ｐ－玻璃微球（３２Ｐ－ＧＭＳ）灌注术，照射剂量６０００～８０００ｃＧｙ，术后３周局部肿瘤脱落。表明３２Ｐ－ＧＭＳ可引起局部内照射及栓塞作用，患者无全身不良反应，无骨髓抑制及肝肾功能损害。灌注后４～５周，对４例行广泛性子宫切除术及腹主动脉旁淋巴结活检，２例作了外照射。本组患者随访１～１．５年均存活。３２Ｐ－ＧＭｓ治疗宫颈癌安全、可靠、一次性完成，对工作人员无辐射危险。

Six patients with exophytic cervical carcinoma (stage≥Ⅱ) wore treated by intra-arterial infusion of phosphorus-32 glass microspheres (32P-GMS) as a preoperative treatment. For each case, 32P-GMS were injected via bilateral uterine arterial catheters. Necrotic process of neoplasm and profuse necrotic discharge were occurred with three weeks after treatment. No myelosuppression, hepatic and renal toxicities were encountered. After initial treatment four to five weeks, four cases underwent radical hyterectomy and paraaortic lymphadenectomy, when the other cases underwent radiation treatment. All patients were followed up in 12-18 months, no death until now. Intra-arterial instillation of 32P-GMS is a simple and safe and may be used as a preoperative treatment of exophytic cervical carcinoma (stage≥Ⅱ).