外阴癌细胞核DNA含量及面积的图像分析研究

Image analysis of the DNA content and nuclear area of the vulvar carcinoma

应用图像分析技术定量测定了３３例外阴鳞癌细胞核的ＤＮＡ含量与面积，并结合随访结果分析了外阴癌的预后因素。结果表明，外阴鳞癌细胞核的ＤＮＡ含量与面积均明显高于正常外阴上皮的测定值，并随组织学分级的增高而增大，直径较大肿瘤的ＤＮＡ含量较高，外阴癌的临床分期与组织学分级相关。患者的预后与临床分期、淋巴结转移、肿瘤大小、组织学分级及ＤＮＡ含量相关，其中临床分期是影响外阴癌患者预后的最重要因素。

The DNA content and nuclear area of 33 cases squamous cell carcinoma of the vulva were studied quantitatively using image analysis technique. Some prognostic factors involving the patients were analyzed too. The DNA content and nuclear area of vulvar carcinoma were significantly higher than them of normal vulvar skin, and increased along with the advance of histopathologic degree. The DNA content was higher in larger vulvar cancer. Clinical stages of the vulvar carcinoma were interrelated with histopathologic degrees. Prognosis of patients with vulvar carcinoma was interrelated with clinical stage,lymphatic,metastases,tumor size,histopathologic degree and DNA content, among which clinical stage was the most important factor .