摘要
研究了载有抗癌药物5-氟脲嘧啶(5-Fu)的磁性牛血清白蛋白微球(FMAM)的药物体外释放测定条件以及与释放相关的特性。实验表明测定的灵敏度和准确度与试液的pH相关,实验提示,在pH6.05~7.50区间内5-Fu可发生烯醇型互变异物转化,用紫外分光法可以测定转化率,实验结果说明微球制备固化温度愈高,则药物释放速度愈慢,在相同的制作工艺下,磁性流体投量增加,则释放速度加快,但在该实验条件下,磁性流体增加至50ul以上时,不受影响.
we established a UY method to determin 5-fluorouracil(5-Fu) released in vitrofrom magnetic bovine serum albumin microsphere carrier. The determining accuracy can beeffectively improved by preparing blank reference and controlling solution pH. This methodhad been applied to the study on releasing characteristics of 5-Fu.
基金
国家自然科学基金
关键词
氟脲嘧啶
紫外分光光度法
磁性流体
5-fluorouracil
ultraviolet spetrophotometry
magnetic microsphere carrier