摘要
红霉素琥珀酸乙酯的合成胡茂连(浙江仙居制药股份有限公司,仙居317300)SynthesisofErythromycinEthylSuccinateHuMao-lian(XianjuPharmaceuticalCo.Ltd317300)Abstrac...
We synthesized erythromycin ethyl succinate through a threestep reaction. First,succic anhydride and ethyl alcothol were refluxed to get succinic acid monoethyl ester, then theproduct was treated with thionyl chloride to get β-carbethoxy; propionyl chloride, and last thromycin reacted with β-carbethoxy-propionyl chloride to get erythromycin ethyl succinate.
关键词
红霉素
琥珀酸乙酯基
合成
erythromycin ethyl succinate
erythromycin
β-carbethoxy propionyl chloride