直肠病变脱落细胞超微结构的研究

Study on the ultrastructure of rectal exfoliative cells

目的 通过直肠病变脱落细胞超微结构的研究,揭示直肠疾病的病因病理特征。 方法 用砂片指套作指诊,采集18例直肠病变脱落活细胞,按序制作超薄切片染色,电镜下观察拍照。 结果 直肠炎症、腺癌、绒毛状腺瘤及其癌变、恶性黑色素瘤细胞的超微结构各有其特征,在电镜下均可分为亮细胞和暗细胞2种;恶性黑色素瘤细胞内黑色素颗粒在亮细胞多成团分布,在暗细胞多散在分布于细胞边缘;绒毛状腺瘤及其癌变的发生可能和细菌感染有关。 结论 直肠病变脱落细胞超微结构的研究,能更加深入地了解直肠疾病的生物学特征。

AIMS The characteristics of etiology and pathology of rectal diseases were revealed by study on the ultrastructure of rectal exfolia-tive cells.METHODS Rectal exfoliative cells were collected by digital examination sticking small pieces of corundum cloth in 18 patients with rectal diseases. Lively cells were extracted and examined by electron microscope.RESULTS All the rectal exfoliative cells were divided into bright and dark cells. Malignant melanoma granules distributed in groups in bright cells, but scatter in pericellular region in dark cells. The development of villous adenoma and its malignant change associated with bacterial infection.CONCLUSIONS Electromicroscopy can get more detailed biology of rectal diseases than light microscopy.