肺表面活性剂治疗新生儿呼吸窘迫综合征6例观察

TREATMENT OF RESPIRATORY DISTRESS SYNDROME WITH SURFACTANT ON 6 NEWBORN INFANTS

6例新生儿呼吸窘迫综合征（平均胎龄和出生体重分别为34.7周及2158g）接受了肺表面活性物质治疗。治疗前，患儿有严重的低氧血症。治疗后15分钟，患儿的肺换气功能明显改善。12小时后，5例患儿根据需要重复使用了活性物质，效果仍很满意。第一剂活性物质治疗后约22小时，平均吸入氧浓度由治疗前的80％降至60％以下。患儿机械通气时，使用了较低的吸气峰压和较高的呼吸频率。6例患儿全部痊愈出院。

Six newborn infants with respiratory distress syndrome whose average gestational age and birthweight were 34. 7 weeks and 2158 grams respectively were treated with surfactant (Curosurf). They had severe hypoxemia before surfactant treatment and their PO2, PO2/FiO2, and a/APO2 values significantly increased 15 min after treating with surfactant(P<0.05). Five infants who still had hypoxemia 12 hours after initiation of treatment received the second dose of surfactant. The result of the second treatment was similar to the first treatment. Pulmonary gas exchange in these infants improved. Meanvalues for FiO2 decreased from 80% to 60% or less than 60% about 22 hours after receiving the first dose of surfactant. Compared to previous method of mechanical ventilation, lower inspiratory pressure and higher respiratory rate were used in sick infants. All of 6 cases of respiratory distress syndrome were cured perfectly