氯氮平对精神分裂症患者预后的影响

Effects of clozapine on the prognosis of patients with schizophrenia

目的探讨氯氟平对精神分裂症疗效及预后的影响。方法对５１例精神分裂症患者进行了交叉对比研究。分别观察了氯氮平和氯丙嗪对精神分裂症的疗效和预后的作用。平均观察期为５０ｍｏ（１３．６、７０ｍｏ）。结果服用氯氮平所需治愈时间较短，复发间隔时间较长，副作用和再次住院次数明显少于服用氯丙嗪。结论氯氮平是治疗精神分裂症及预防复发较为理想的药物。

Objective To search for the influence of clozapine on prognosis of patients withschizophrenia.Methods A cross comparison study was usedin fifty- one patients with schizophrenia. The therapeutical effects and the prognosis of patientswith schizophrenia treated by clozapine and chlorpromazine were observed prospectively. The mean duration of study was 50 months (13. 6 to 70 months).Results The findings show that the patients treated with clozapine, the need curative time was significantly shorter but the relapes interval longer thah group of chlorpromazine. The rehospitali-zation time or side-effects of clozapine are fewer than that of the patients treated with chlorpromazine.Couclsion The therapeutical effects of clozapine are better than that chlorpromatine in acutive treatment and prevent relapes of schizophrenia.