加贝酯治疗急性胰腺炎的临床研究

Clinical study on gabexate mesilate in the treatment of a-cute pancreatitis

目的 探讨国产加贝酯对急性水肿型胰腺炎的疗效和不良反应。 方法 应用加贝酯和一般常规治疗方法对158例年龄在20-60岁的急性水肿型胰腺炎患者进行多中心、随机、对照临床研究,其中加贝酯组81例,一般常规治疗(对照组)77例。 结果 加贝酯组显效率(74.1％)及总有效率(100％)均高于对照组(41.5％及94.8％),加贝酯组疗效显著优于对照组(P<0.01和P<0.05),且不良反应少而轻,除3例(3.7％)注射局部皮肤发红、疼痛,2例(2.4％)静脉炎,1例皮疹外,未发现肝、肾、心及血液损伤。 结论 国产加贝酯治疗急性胰腺炎起效迅速,疗效肯定,副反应少而轻。对60-80岁的急性胰腺炎患者亦有较好疗效。

AIM Therapeutic and side effects of domestic gabexate mesilate(GM) in the treatment of acute edematous pancreatitis were observed. METHODS A total of 158 patients (age 20 - 60 years old) with acute edematous pancreatitis were randomly allocated into 2 groups in a multi-center controlled clinicatl trial. Of these, 81 patients were treated with GM and 77 by the convintional methods as the control group. RESULTS The notable effective rate and total effective rate were 74.1% and 100% respctively in GM treatment group, and 41.5% and 94.8% respectively in the control group. The effect in GM treatment group was significantly higher than that in the control group ( P < 0.01 and F < 0. 05). There were less and slight side effects in GM treatment group. 3 patients (3.7%) presented reddness and pain in injected part of skin, 2 patients (2. 4%) phlebitis and one patient drug eruption. No dysfuction in hematopoietic, blood coagulation, liver and kindey, or ECG change was found.CONCLUSION There is not only quick action and satisfactory therapeutic efficacy, but also less and slight side effect in GM treatment of acute pancreatitis. There are also good curative effects in the 60 - 80 years- old patients.