慢性肝病60例血浆内毒素与生化、病理和中医证型关系的研究

The relationship between plasma endotoxin and liver function, pathology and TCM syndromes in chronic liver diseases

目的 探讨慢性病毒性肝炎、肝硬化血浆内毒素的变化与肝脏病理、生化、中医证型的关系及其临床意义。 方法 1993年3月至12月对慢性肝病60例采用基质显色法鲎试验定量检测血浆内毒素。 结果 CAH重型血浆内毒素均值明显高于CPH及CAH轻型(P<0.05);与Bil呈正相关,与PA呈负相关。血瘀血热型内毒素均值明显高于肝郁脾虚型(P<0.05)。 结论 检测血浆内毒素含量可以作为判断肝病病情轻重的指标之一,并为中医辨证提供了客观依据。

AIM To study the relationship and clinical significance between plasma en-dotoxin (PE) levies and liver function, pathology and TCM syndromes in chronic liver diseases.METHODS The synthetic chromogenic limulus amebocyte lysate assay was adapted to determine the concentration of PE in 60 patients with chronic liver diseases from March to December 1993.RESULTS The PE levels were higher in severe chronic active hepatitis than mild chronic active hepatitis and chronic persistent hepatitis (P<0.05). There was a positive correlation in PE and serum bilirubin, and negative in PE and prothrombin time activity. The PE levels were higher in blood- stasis and blood- heat syndrome than that in liver- depression and spleen asthenia syndrome(P<0.05).CONCLUSIONS The changes of PE in chronic liver diseases is valuable as a marker in determination of the severity of liver diseases, and is an objective evidence in TCM differenciation of symtomes and signs.