重组人粒细胞巨噬细胞集落刺激因子治疗骨髓抑制

Treatment to bone marrow depression with recombinant human granulocyte-macrophage colony-stimulating factor

用重组人粒细胞巨噬细胞集落刺激因子（ｒＨＧＭ－ＣＳＦ）治疗放射及化学治疗所致的骨髓抑制１８例（男性１２例，女性６例；年龄４７±ｓ８ａ）。ｒＨＧＭ－ＣＳＦ３００μｇ，ｓｃ，ｑｄ或ｑｏｄ。升白泰组１５例（男性１０例，女性５例；年龄４８±７ａ），升白泰冲剂１５ｇ，ｐｏ，ｔｉｄ；安慰剂组８例（男性５例，女性３例：年龄４６±９ａ），维生素Ｃ０．２ｇ，ｐｏ，ｔｉｄ。结果：治疗组白细胞和中性粒细胞数升高多于对照组（Ｐ均＜０．０１）。

Eighteen patients(M12,F6;age 47± s 8a)with bone marrow depression resulting from chemotherapy and radiotherapy were treated with recombinant human granulocyte-macrophage colony-stimulating factor(rHGM-CSF) 3 00 μg, sc, qd or qod.Another two groups were Sheng-bai-tai group(15 patients,M 10,F5;age 48± 7 a.treated with Sheng-bai-tai,the infusion of traditional Chinese medicine,15 g,po,tid)and placebo group(8patients,M5,F 3;age 46± 9 a,treated with vitamin C 0.29,po.tid)served as controls.Results showed that leucocyte total counts and neutrophils counts of rHGM-CSF group were significantly higher than that of controls(P both<0.01).