甘糖酯对慢性阻塞性肺疾病病人血中脂质过氧化物及抗氧化酶的影响

Influence of Gan-tang-zhi on blood lipid peroxidation and antioxidant enzyme activity in patients with chronic obstructive pulmonary diseases

慢性阻塞性肺疾病４０例，随机分为２组。甘糖酯组２２例（男性１７例，女性５例：年龄６３±ｓ１１ａ）在常规治疗基础上加用甘糖酯２００ｍｇ于５％葡萄糖氯化钠注射液５００ｍＬ中静脉滴注。ｑｄ，共１０ｄ。并与常规治疗组１８例（男性１３例，女性５例；年龄６７±６ａ）对照。结果：治疗后２组脂质过氧化物（ＬＰＯ）均显著降低（Ｐ＜０．０１）：谷胱甘肽过氧化物酶及过氧化氢酶（ＣＡＴ）均显著升高（Ｐ＜０．０１）：经组间比较，ＬＰＯ的降低，ＣＡＴ的升高以甘糖酯组更显著（Ｐ＜０．０５）。

Forty patients with chronic obstructive pulmonary diseases (COPD) were divided into 2 groups at random.Twenty-two patients(M17;F5;age 63±s 11a) received Gan-tan-Zhi 200 mg in 5% glucose in normal saline 500 mL or 5% glucose 500 mL iv drip qd and 18 patients(M 13,F5;age 67±6a) received routine treatment served as control,all were treated for 10 d.The values of glutathione peroxidase(GSH-Px),catalase (CAT) and GSH-Px/LPO(lipoperoxide) in 2 groups were all increased distinctly,the level of LPO in 2 groups fell(P<0.01).But the increase of CAT and the decrease of LPO in Gan-tang-zhi group were greater than those in routine treatment group(P<0.05).