卡替洛尔对心肌收缩力的影响

Effect of carteolol on myocardial contraction

２６例男性健康志愿者（年龄２４．０±ｓ１．３ａ）按随机双盲法各１３例，用β阻滞剂卡替洛尔或安慰剂各１０ｍｇ，ｐｏ，ｑｄ，共８ｄ。服药前后作运动负荷试验，负荷前后检查收缩时间间期。结果：卡替洛尔不具有明显负性肌力作用，并在整个负荷中无快速心率的发生。提示卡替洛尔具有负性变时作用，这种临床药理效果可能有利于潜在心功能低下病人的治疗。

Twenty-six healthy volunteers were randomly divided into two groups to received carteolol,a new β-receptor blocker and placebo respectively by double-blind method.The dose of carteolol or placebo was 10 mg/d,po,qd,for 8 d.Exercise tests were determind in both groups before and after medications.Results showed that no prolongation of PEP(preejection period) was found after exercise test in both groups.Correlation coefficeints between STI(systolic time interval-QS2,LVET,PEP) and heart rate were statistically significant(P<0.01) in placebo group,but not in carteolol group.It suggested that carteolol has no significant relative negative inotropic action on cardiac muscule and has advantage to treat the latent dysfunction of heart disease by its negative chronotropic action.