法莫替丁与奥美拉唑治疗消化性溃疡急性大出血的对比

Famotidine vs omeprazole in treating peptic ulcer with acute massive bleeding

目的：观察大剂量法莫替丁与奥美拉唑治疗消化性溃疡急性大出血的疗效。方法：６０例急诊内镜窥示有活动性出血或新近出血征象的消化性溃疡病人，随机分为２组。法莫替丁组（男性２７例，女性３例，年龄４６±ｓ１７ａ）接受法莫替丁４０ｍｇ加生理盐水２０ｍＬ，ｉｖ，ｑ１２ｈ，连续３ｄ，奥美拉唑组（男性２６例，女性４例，年龄４５±１６ａ）接受奥美拉唑４０ｍｇ，ｉｖ，ｑ１２ｈ，连续３ｄ。结果：２组病人均止血成功。法莫替丁无不良反应。２组病人的输血量、大便隐血转阴天数、住院无数均无显著差异（Ｐ＞０．０５）。结论：大剂量法莫替丁治疗消化性溃疡急性大出血的疗效与奥美拉唑相似。

AIM: To observe the therapeutic effect of intravenous large dosage famotidine and omeprazole in treating peptic ulcer with acute massive bleeding. METHODS: Sixty Patients endoscope shown peptic ulcer with active bleeding or recent bleeding signs, were divided into 2 groups at random. The famotidine group(M27,F3 ; age 46± s 17 a) received famotidine 40 mg in normal saline 20 mL iv, q 12h,for 3 d. The omeprazole group(M 26, F 4; age 45 ± 16 a) received omeprazole 40 mg, iv,q 12h,for 3 d. RESULTS: Definite hemostasis of 2 groups were all achieved. There were no adverse reactions in the famotidine group.Regarding to doses of blood transfusion,the days of hospitalization, and the days of turning stool occult blood tests to negative, there were no significant difference between 2 groups(P>0.05). CONCLUSION: The therapeutic effect of intravenous large dosage famotidine on peptic ulcer with acute massive bleeding was similar to omeprazole.