十六角蒙脱石治疗婴幼儿腹泻病104例

Dioctahedral smectite in treating 104 infantile diarrhea

目的：观察十六角蒙脱石治疗婴幼儿腹泻病的疗效。方法：单纯婴幼儿腹泻病１１５例，其中治疗组６０例为Ａ组，采用十六角蒙脱石１－２ｇ，ｐｏ，ｔｉｄ，疗程３ｄ：对照组５５例为Ｂ组，采用阿米卡星、利巴韦林或双黄连治疗。另外，有其他感染合并腹泻８５例，其中治疗组４４例为Ｃ组，在治疗原发病基础上加服十六角蒙脱石。方法及疗程同Ａ组，对照组４１例为Ｄ组，在治疗原发病基础上加服庆大霉素、胃酶合剂。结果：Ａ和Ｂ２组总有效率依次为９７％和６９％（Ｐ＜０．０１）；Ｃ和Ｄ２组止泻时间依次为１．８±０．８ｄ和２．５±１．１ｄ（Ｐ＜０．０１）。结论：十六角蒙脱石对单纯性和其他感染合并腹泻均有效，无明显不良反应。

AIM: To observe the effects of dioctahedral smectite(DS) in treating diarrhea of infant. METHODS: One hundred and fifteen patients with single diarrhea were divided into 2 groups. Group A, 60 patients received DS 1-2g,po, tid, for 3 d. Group B, 55 patients were given amikacin, ribavirin or Shuang-huang-lian, moreover, 85 diarrhea patients with other infection who simultaneously received the therapy of origin disease were divided 2 groups also. Group C (44 patients) were given DS. The is same to group A. Group D (41 patients) received gentamicin and pepsin mixture. RESULTS: the total response rates of group A and B are 97%, 69%(P< 0.01), respectively. The period of stopping diarrhea of group C and D are 1. 8±0.8d, 2.5±1.1d(P< 0.01), respectively. CONCLUSION: DS is a effective drug for treating both single diarrhea and diarrhea with other infection diseases and obvious adverse reactions were mild.