特布他林与氨茶碱治疗小儿喘息性疾病的比较

Terbutaline vs aminophylline in treating pediatric asthmatic diseases

目的：比较特布他林与氨茶碱治疗小儿喘息性疾病的近期疗效。方法：特布他林组５０例（男性２４例，女性２６例；年龄４±ｓ３ａ），其中喘息性支气管炎２３例，婴幼儿哮喘１４例，儿童哮喘１３例；采用特布他林０．０５ｍｇ／ｋｇ，ｐｏ，ｔｉｄ，７ｄ为一个疗程。另设氨茶碱对照组５０例（男性１８例，女性３２例；年龄５±３ａ），其中喘息性支气管炎２１例，婴幼儿哮喘１６例，儿童哮喘１３例；采用氨茶碱３－５ｍｇ／ｋｇ，ｐｏ，ｔｉｄ，７ｄ为一个疗程，２组均同时应用常规剂量的青霉素防治感染。结果：特布他林组总有效率为９２％，对照组为６０％（Ｐ＜０．０５）；２组不良反应均小。结论：特布他林治疗小儿喘息性疾病疗效优于氨茶碱。

AIM:To compare the short-term curative effects of terbutaline vs aminophylline in treatment of pediatric asthmatic diseases. METHODS: Terbutaline group (M 24, F 26; age 4±s 3 a, asthmatic bronchitis 23 cases, infant asthma 14 cases and children bronchial asthma 13 cases) received terbutaline 0. 05 mg/kg, po, tid, for 7 d. Aminophylline group(M 18, F32; age 5±3 a, asthmatic bronchitis 21 cases, infant asthma 16 cases and children bronchial asthma 13 cases) received aminophylline 3-5 mg / kg, po, tid, for 7 d. Penicillin of customary dose was used for preventing infections in 2 groups. RESULTS: The total response rates were 92% in terbutaline group and 60% in amillophylline group(P<0.05), No serious adverse reaction was observed. CONCLUSION: The curative effect of terbutaline was better than that of aminophylline in treatment of pediatric asthmatic diseases.