高血压大鼠左室肥厚消退后的心电活动变化

Experimental Study on Changes of the Heart Electrophysiological Activities After Regression of Hypertensive Left Ventricular Hypertrophy

用尼群地平、卡托普利治疗自发性高血压大鼠，逆转其左室肥厚，比较左室肥厚消退前后心电活动变化。结果发现，两药均可使左室肥厚消退，与同周龄自发性高血压大鼠相比，两药物治疗组单相动作电位复极化９０％时程（ｍｓ）缩短（分别为８７±９ＶＳ１０４±１４；９０±９ＶＳ１０４±１４，Ｐ均＜０．０５），室颤阈值（ｍＡ）提高（分别为１６．７５±４．４３ＶＳ８．７５±３．８８；２０．００±５．４０ＶＳ８．７５±３．８８，Ｐ均＜０．０５），氯化铯诱发心律失常的发生率降低，各指标值与同周龄ＷＫｙ鼠相近。表明随着左室肥厚消退，心电活动异常也得到改善。

In the study,two groups of spontaneously hypertensive rats(SHR)were treated with nitrendipine or captoprial,After the regression of hypertensive left ventricular hypertrophy in the two treated groups,the fiffernces of heart electrophysiological activities were studied between the two groups of treated SHR and the group of untreated SHR.In the two treated groups,the monophasic action potential duration at 90%repolarization was shorten(87±9VS 104±14 ms,P<0.05;90±9VS 104±14ms,P<0.05),the ventricular fibrillation threshold was increased(16.75±4.43 VS 8.75±3.88 mA,P<0.05;20.00±5.40VS 8.75±3.88mA,P<0.05),the occurrence of arrhythmias induced by CsCl was reduced.All of the changes above become similar to the findings of the some age Wistar-Kyoto rats.The results demonstrated that after the regression of hypertensive left ventricular hypertrophy,the heart electrophysiological activities were improved to become normal.