摘要
本实验研究了1日龄雏鸡感染CIAV后免疫器官T细胞的IL-2、IFN、CSF诱生活性、T细胞与B细胞增殖反应的动态变化。结果表明,雏鸡感染CIAV后:(1)胸腺和脾脏T细胞IL-2诱生活性分别于7~21d不17~14d明显降低;(2)脾脏淋巴细胞IFN诱生活性于7~14d显著减弱;(3)胸腺淋巴细胞CSF诱生活性于14d未见异常,21d明显升高;(4)胸腺和脾脏T细胞增殖反应分别于14d和7~21d明显减弱:(5)法氏囊和脾脏B细胞增殖反应分别于7~21d和21d显著减弱;(6)胸腺重量与体重比值、法氏囊重量与体重比值、体重均明显降低;(7)外周血液PCV、RBC、Hb、WBC、血栓细胞(血小板)数值均明显降低。
Experimental studies were conducted on kinetic alterations in the activities ofinterleukine-2(IL-2), interferon(IFN) and colony-stimulating factor (CSF) in lympho-cytes and transformation responses of T and B lymphocytes in the immune organs ofchicks infected with chicken infections anemia virus(CIAv) at 1 day of age, The resultsare as follows:(1) IL-2 activity in T lymphocytes from both of the thymus and spleenwere markedly decreased 7~21 days and 7~14 days postinfection(PI),respectively.(2)IFN activity in splenic lympliocytes were noticeably reduced 7~14 days PI.(3) CSFactivity in thylnic lymphocytes was not significantly influenced 14 days PI. but it waselevated 21 days PI.(4) T lymphocyte transformation responses in the thymus and spleenwere both significantly decreased 14 days and 7~21 days PI, respectively.(5)DecreasedB lymphocyte transformation responses in bursa of fabricius and spleen were recorded7~21 days and 21 days PI, respectively.(6) Thymus-to-body weight ratios, bursa-to-body weight ratios and body weights were all remarkably reduced PI.(7)PCVs, RBC,Hb, WBC and thrombocytes in the periplieral blood were all significantly reduced PI.
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
1995年第3期233-238,共6页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金
关键词
感染
雏鸡
细胞因子
免疫功能
传染性贫血病毒
Chicken infectious anemia virus, Chick, Interleukine-2, Interferoncolony-stimulating factor,Immune function