异种表面角膜镜片术的动物实验和初步临床应用

Experimental and clinical studies on heteroepikeratophakia

对5只实验猴进行了异种(人→猴)表面角膜镜片术,术后7～10天上皮完全覆盖镜片,3～6个月角膜细胞再生,排列正常,结果4只实验猴镜片透明愈合,没有发生排斥反应。1只实验猴术后发生层间上皮植入性囊肿。观察时间;3～24个月。在临床上为2例单眼无晶体眼进行了异种(猴→人)表面角膜镜片术,术后镜片稍有水肿,以后逐渐消失,5～8天上皮完全修复,镜片一直透明,没有发生排斥反应,视力也得到了明显改善。

In the experimental study 5 cases of heteroepikeratophakia (HEP) (human to monkey) were done. The results showed that 4 HEP of experimental monkeys were found to be transparent in 6～24 months after operation. One of five experimental monkeys failed to have a transparent HEP because of epithelia implantation between donor lenticule and host cornea in the 3rd month after operation. In clinical study, HEP (monkey to human) was performed on 2 patients with aphakia. The visual acuity of these patients were improved because the transparent HEP was achieved. Either in experimental or in clinical study the immunological rejection was not found.