环丙沙星滴眼液治疗外眼细菌性炎症的临床观察

A clinical investigation of 0.3% ciprofloxacin eyedrops in the treatment of bacterial conjunctivitis and keratitis

环丙沙星是喹诺酮类新一代抗菌素药物。为评价该药局部应用治疗外眼细菌性炎症的临床效果,采用国内研制的0.3%环丙沙星滴眼液治疗急性细菌性结膜炎60例、细菌性角膜炎30例,并用0.3%诺氟沙星滴眼液设置对照组。试验组两种疾病的痊愈率分别为95%及80%,有效率分别为100%及96.7%,均高于对照组,但两组差异无统计学意义。试验组的平均治愈天数显著短于对照组。在培养出的菌株中,对环丙沙星和诺氟沙星的敏感比率分别为99.3%及89.9%,两者差异有显著性意义。最低抑菌浓度测定显示前者具有更高的抗菌活性。不良反应仅为个别患者轻微一过性刺激症状。

A clinical investigation on the treatment of 163 cases of acute bacterial conjunctivitis and bacterial keratitis with 0.3% ciprofloxacin and norfloxacin eyedrops was carried out from May to December, 1993. It showed that the cure and effective rate of the former was 90% and 98.9%. There was no significant difference between the two drugs. No serious side effects occurred.