玻璃体注射汉防己甲素的药代动力学研究

Clearance of tetrandrine from vitreous

采用高效液相色谱法(HPLC)测定汉防己甲素玻璃体注射后的药代动力学过程,32只兔眼玻璃体内注射200μg汉防己甲素后,按测定时点取房水、玻璃体测量其浓度,结果表明:汉防己甲素玻璃体注入后玻璃体内药物浓度时量曲线呈二室模型,T_(1/2)(α)为1.02小时,T_(1/2)(β)为16.62小时。房水药物浓度极低,两小时出现峰浓度约6.73μg/ml。

The pharmacokineties of intravitreally injected tetrandrine was monitered by high-performance liquid chromatography (HPLC). After intravitreal injection of tetrandrine in rabbits' eyes, aqueous humor and vitreous were drawn at different times for determination. The drug concentration in the aqueus humor and vitreous was measured by HPLC. The results showed that the concentration-time curves of tetr-andrinc in the vitreous fitted in with a two-compar-tment open model with half-life periods of 1.02 hour(α) and 16.62 hour (β) respectively. The drug concentration in aqueous humor was low, with a peak value of 6.73μg/ml at two hour.