视网膜下液碱性成纤维细胞生长因子的临床意义

Clinical Significance of Basic Fibroblast Growth Factor in Subretinal Fluids

采用“三明治”酶链免疫分析法，检测了４３例患有视网膜脱离的视网膜下液的碱性成纤维细胞生长因子（ｂＦＧＦ）的含量。结果显示随着增殖性玻璃体现网膜病变（ＰＶＲ）严重程度的增加，样品中ｂＦＧＦ的含量也增加。高含量的ｂＦＧＦ将促进在ＰＶＲ收缩膜中占主要成分的视网膜色素上皮细胞的迁移和增殖。因此，ｂＦＧＦ有可能在ＰＶＲ的发展过程中起着重要的作用。

sing a sandwich-type enzyme-linked immunosorbent assay, the levels of basic fibroblast growth factor(bFGF)in 43 subretinal fluids with retinal detachment were detected.The data showed that as the severity ofproliferative vitreoretinopathy(PVR)increased, the levels of bFGF from these samples likewise increased.These elevated levels of bFGF might be sufficient to stimulate migration and proliferation of retinal pigmentepithelial cells which are major components of contractile cellular membranes in PVR. Basic FCF appears toplay an important role in the course of development of PVR.