原发性孔源性视网膜脱离视网膜下液纤维连接蛋白含量与PVR形成关系的探讨

Studies on Fibronectin level in the SRF of RRD and Its Relation to PVR Formation

用ＥＬＩＳＡ方法观察到４１例原发性孔源性视网膜脱离患者视网膜下液中纤维连接蛋白的含量为０．５～８０ｕｇ／ｍｌ，非ＰＶＲ组２０例，轻度ＰＶＲ组１１例，重度ＰＶＲ组１０例，三组之间有明显差异（Ｐ＜０．００１）。视网膜下液中纤维连接蛋白含量随ＰＶＲ分级增高而增加，而患者血浆中纤维连接蛋白的含量正常，视网膜下液中纤维连接蛋白的含量与血浆中纤维连接蛋白的含量无相关性，视网膜下液中纤维连接蛋白的含量取决于血一视网膜屏障破坏的严重程度。

ith ELISA method,we Observed that the concentration of the fibronectin ( FN )in subretinal fluid(SRF)in 41 cases of rhegmatogenous retinal detachment(RRD)ranged from0.5-80ug/ml.Significant dif-ference(P<0. 001) was showed among three groups(non-PVR group ,20 cases ; light PVR group ,11 cases,and heavy PVR group,10 cases).The concentration of FN in SRF was positively correlated with its grades of PVR. The concentration of serum FN was normal. No correlation was found between the FN in SRF and serum.Theamount of FN in SRF was related with the extent of breakdown of blood-retinal barrier.