摘要
新型多巴胺受体激动剂多培沙明（ＤＰＸ）能显著减轻缺氧和缺血豚鼠心室乳头肌静息电位，动作电位幅度和Ｏ相除极速度的降低程度及动作电位时程的缩短程度，其减轻作用明显大于非诺多泮（ＦＯＤＡ）和丙卡特罗（ＰＣＴＲ）。ＤＰＸ能使缺氧时缩短的有效不应期（ＥＲＰ）延长，而使缺血时延长的ＥＲＰ缩短，其程度明显大于ＦＯＤＡ与ＰＣＴＲ。提示ＤＰＸ抗缺血性心律失常的作用优于其他类型的多巴胺激动剂。
The effects of
dopexamine(DPX),a new dopamine receptor agonist ,ontransmembrane
potential and effective refractory period(ERP)of isolated guinea pig
ventricularmuscle superfused either with hypoxia or mimic ischemia
perfusates were investigated by usingintracellular microelectrede
technique and compared with fenoldopam(FODA) and procaterol.DPX(3 ×
10-6mol·L-1) was found to significantly reduce both the extent of
decrease of resting poten-tial ,action potential amplitude and
maximal upstroke velocity and the degree of shortening of
actionpotential duration caused by hypoxia or ischemia,These effects
of DPX were significantly greater thanthose of FODA and procaterol
albeit the latter showed effects similar to DPX,DPX could not
onlylengthen the abbreviated ERP resulting from hypoxin,but also
shorten the prolonged ERP caused byischemia.This action of DPX was
more evident than that of FODA and procaterol.The results revealthe
potential advantages of DPX over other dopaminergic agonists in the
antiarrhythmic activity duringmvocardial ischemia.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第3期161-167,共7页
Acta Pharmaceutica Sinica
关键词
多培沙明
心肌缺血
跨膜电位
有效不应期
Dopexamine
Myocardial ischemia
Transmembrane potential
Effective
refractoryperiod
