摘要
业已证明，丹酚酸Ａ有较强的抗氧化和清除自由基等多方面的作用。本实验用大鼠半乳糖性白内障模型，研究局部应用丹酚酸Ａ对白内障形成的影响。结果表明，局部用０．０５％的丹酚酸Ａ（每日滴眼两次）对白内障的形成有一定的抑制作用，使白内障形成过程减缓。而且给药组动物晶体内过氧化氢和脂质过氧化产物（ＭＤＡ）含量减少，蛋白巯基和总巯基增加。体外实验表明，丹酚酸Ａ对醛糖还原酶有一定抑制作用。以上结果提示，丹酚酸Ａ可通过不同途径抑制白内障的形成，对糖性白内障的防治有一定意义。
Salvianolic acid A has been
demonstrated to have efficient antioxidative and freeradical
scavenging effects. In the present experiments,the preventive effects
of salvianolic acid A ongalactose-induced cataract in rats were
investigated. Dropping 0.05%salvianolic acid A in the eyes(two times
a day) was found to delay the development of cataract. The contents
of MDA and H2O2 inthe cataract lens were decreased in salvianolic
acid A treated rats. The Protein and non-protein thiols inthe
cataract lens of the salvianolic acid A treated rats were higher than
those of control rats. In in vitroexperiments salvianolic acid A was
shown to inhibit aldose reductase activity. These results
indicatethat sallvianolic acid A can prevent galactose-induced
cataract by antioxidation and inhibition of aldose reductase.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第8期561-566,共6页
Acta Pharmaceutica Sinica
关键词
半乳糖性
白内障
丹酚酸A
抑制作用
Galactose- induced cataract
Salvianolic acid A
Aldose reductase
Lipid-peroxidation
