粉防己碱对犬缺血心肌的保护作用

PROTECTIVE EFFECTS OF TETRANDRINE ON ISCHEMIC MYOCARDIA IN ANESTHETIZED DOGS

粉防己碱（Ｔｅｔ）ｉｖ８００ｕｇ·ｋｇ－１可使麻醉犬血压—过性降低，与此同时对血流动力学诸项指标的影响较小。结扎犬冠脉后，能降低犬室颤的发生率及死亡率，降低缺血心肌丙二醛的形成，减少胞内ｃａ２＋的蓄积和ＣＰＫ的释放，以上结果表明，Ｔｅｔ对缺血心叽有良好的保护作用。

The present study indicates that iv tetrandrine may transiently decrease bloodpressure ,while other hemedynamic parameters such as LVP,±dp/dt max,LVEDP, HR and CO maynot be significantly altered. During coronary occlusion three of five dogs developed ventricular fibrillation (VF)and died inthe control group,i.e incidences of VF and mortality were 60%, While tetrandrine(Tet)appeared toreduce the severity of ischemic injury.It may alleviate arrhythmia and prevent VF and death in fourof the five dogsalso attenuated Ca2+ accumulation in myocardial cell ,reduced melondialdehyde(MDA)production in ischemic myocardial and decreased CPK release in comparison with the control.It appears that Tet may have significant protective effects against ischemia induced cardiacdamage in anesthetized dogs.