药物疗效评价的四分结果模式及临床应用

The Quadripartite-Resulted Modality in Evaluating The effecacy of drugs and Worded Example in Clinical Practice

药物疗效评价迄今沿用二分结果模式.该模式无视治疗一对照差的临床意义和检验的功效,有时导致错误治疗决策.作者曾提出四分结果模式;承认新药疗效优于旧药,新旧药疗效差别没有临床意义,否认新药疗效优于旧药,和结果不定.它产生准确决策.本文以临床家可接受的语言说明由二分到四分结果模式的扩展过程,以实例展示其临床应用,并讨论其理论和实践意义以及应用前景.

The dichotomus-resulted modality has been applied in evaluating the efficacy of drugs, The modality disregardes the clinical aignificance of treatment-control difference and the power of test so that it may lead to wrong therapeutic decisions sometimes, Zhao et al (1994) proposed the quadripartite-resulted modality; It is recognized that the efficacy of the new drug is superior over that of the old one, there is no clinical significance with respect of the therapeutic difference between the new and the old drugs, it is rejected that the efficacy of the new drug is superior over that of the old one, and the result is indeterminate, It yields precise decisions, The extension from the dichotomous- to the quadripartite- resulted modality is described usingthe language being acceptable for clinicians. A worked example illustrates its use in clinical practice , Its theoretical and practical significance and its perspective are discussed.