摘要
在K2HPO4,NH4Cl+NH3和NaOH的10%(v/v)乙醇水溶液中,除0.01mol·L-1以上NaOH液作为支持电解质外,麦迪霉素的伏安波皆为两个峰。峰A相当于它的甲醛基还原波,峰B为催化吸附氢波。溶液pH对两峰有强烈的影响。实验表明伏安波有吸附特性,且不可逆。两峰的ip与麦迪霉素的浓度成正比,线性范围分别为3×10-6~3×105-5mol·L-1和1×10-7~4×10-5mol·L-1,检测限为:1×10-6mol·L-1和5×10-8mol·L-1。可应用于麦迪霉素的定量测定。研究了两峰的特性和电极机理,测定了有关的物理常数。
In the system of K2HPO4 or NH3aqueous solution containing
10%(V/V)alcohol ,the voltammetric waves of midecamycin showed two
peaks, but only one peak in NaOH baseelectrolyte.The first peak
corresponds to the reduction of an aldehyde group and the second
peak is thecatalytic adsorption hydrogen wave. The pH of the solution
affects strongly both peakS.Experimentalresults showed that the
voltammetric wave of midecamycin has adsorption and the polarographic
proce-sses of both peaks are irreversible,The peak currents of both
peaks are directly proportional to theconcentration of midecamycin.
The linear ranges are 3×10-6~3×10-5 mol·L-1 and 1× 10-7~4×
10-5mol·L-1and the detection limits are 1×10-6mol·L-1 and 5×10-8
mol·L-1,respectively.It can be used for the determination of
midecamycin. The properties of the peaks and theelectrode mechanism
have been studied and some physical constants were determined.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第1期34-40,共7页
Acta Pharmaceutica Sinica