摘要
本实验采用脑缺血再灌注损伤造成小鼠学习记忆功能障碍模型。通过跳台和避暗实验法研究了丹酚酸对记忆获得功能障碍的改善作用。结果表明丹酚酸Ａ３，１０ｍｇ·ｋｇ－１ｉｖ可以减轻脑缺血再灌注导致的小鼠学习记忆功能障碍状态。并使小鼠脑缺血再灌注后脑组织中脂质过氧化产物ＭＤＡ含量明显降低。体外实验表明丹酚酸Ａ１０－８～１０－７’ｍｏｌ·Ｌ－１可以抑制大鼠脑组织匀浆脂质过氧化反应和羟自由基（·ＯＨ）的生成，表现出较强的抗氧化作用，提示丹酚酸改善脑缺血再灌注损伤的主要机制可能与其抗氧化作用有关。
In the present experiments,an impairment of memory model was
made by cerebral ischemia-reperefusion in mice.Sal A at the dosage
of 3 and 10 mg·kg-1iv was shown to improve the impairment of memory
function induced by cerebral ischemia-reperefusion in step down
and step through tests.In these tests,the number of errors of Sal A
treated group was less and the latency was longer than that of
control group.Meanwhile,Sal A 3 and 10 mg·kg-l iv was found to
reduce the MDA contents in the cortex, hippocampus and striatum of
cerebral ischemia-reperfused rats in vivo.Sal A 10～100 nmol·L-1
was shown to inhibit the brain lipid-peroxidation and scavenge the
free hydroxyl radical in vitro, These results indicate that the
antagonistic effects of Sal A on impairment of learning and memory
caused by cerebral ischemia-reperefusion may be related with its
anti-oxidant activity.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第3期184-190,共7页
Acta Pharmaceutica Sinica
关键词
脑缺血
再灌注
丹酚酸A
学习
记忆
过氧化脂质
Salvianolic acid A
Cerebral ischem
ia-reperefusion
Learning
Memory
Cerebral lipid-peroxidation
Hydroxyl radical
