黄褐毛忍冬皂甙对对乙酰氨基酚致小鼠肝脏毒性的保护作用

PROTECTIVE EFFECT OF THE FULVOTOMENTOSIDES ON PAKACETAMOL-INDUCED HEPATOTOXICITY IN MICE

黄褐毛忍冬皂甙对对乙酰氨基酚致小鼠肝脏毒性的保护作用时京珍，刘耕陶（贵阳贵州省中医研究所５５０００２；中国医学科学院药物研究所１０００５０）我们已报道黄褐毛忍冬总皂甙对实验性肝损伤有保护作用［１］。经进一步实验发现其中的两种成分，即Ｈ和Ｓ均为保肝作用...

Fulvotomentoside α-hederin (H) and sapindoside B(S) are two components of thefulvotomentosides reported to decrease the toxicity of a number of hepatotoxins in mice.We studiedthe effects of the mixture of α-hederin and sapindoside B(HS)on paracetamol(Par)-induced liverinjury.HS(20 mg· kg-1 sc twice) was shown to decrease the mortality produced by Par.The liverin jury produced by Par was remarkably decreased as indicated by dec rease of sGPT and byhistopathological examination,Additionally,HS mitigated the hepatic GSH depletion caused by Par。Par excretion into urine was increased following HS。