摘要
以己酸孕酮注射液为例，研究了药物在自然光和不同灯光照射下的含量变化规律，预测了药物在室内自然光照射下的贮存期。找出了不同光源对药物稳定性影响的等效数量关系，使在今后的研究中可以用灯光为光源预测药物在室内自然光照射下的贮存期。己酸孕酮注射液在光照试验中含量变化服从零级反应规律：Ｃ＝Ｃ０－Ｋ（Ｅｔ），在室内自然光照射下的贮存期约为１．９年。
The photodegradation of drugs under
natural light and various lamp lightirradiation was studied and the
shelf-life of drugs under indoor natural light irradiation was
predictedwith hydroxyprogesterone caproate injection as an
example.The equivalent influences of differentlight sources on the
photostability of the above drug were obtained.Therefore,the natural
lightphotostability and the shelf-life of drugs under indoor natural
light irradiation can be studied with lamplight exposure experiment。
The photodegradation of hydroxyprogesterone caproate injection obeys
zero order kinetics :C=C0-kEt,and its shelf-life under indoor natural
light irradiation is about 1.9 years.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第4期298-301,共4页
Acta Pharmaceutica Sinica
关键词
光稳定性
贮存期预测
己酸孕酮
药物鉴定
Photostability
Shelf-life prediction
Hydroxyprogesterone
caproateUndergraduate student
