中药羌活中的香豆素

COUMAPINS FROM NOTOPTERYGIUM INCISUM TING

从中药羌活ＮｏｔｏｐｔｅｒｇｉｕｍｉｎｃｉｓｕｍＴｉｎｇ．中分离鉴定了１５个香豆素，其中３个新化合物，分别为乙基羌话醇（ｅｔｈｙｌｎｏｔｏｐｔｅｒｏｌ，ＸＩＩ），羌活酚缩醛（ｎｏｔｏｐｔｏｌｉｄｅ，ＸＩＩＩ）和环氧脱水羌活酚（ａｎｈｙｄｒｏｎｏｔｏｐ－ｔｏｌｏｘｉｄｅ，ＸＩＶ）。１２个已知化合物（１～ＸＩ，ＸＶ）分别为佛手内酯、异欧芹素乙、去甲呋喃羽叶云香素、佛手酚、羌活醇、羌活酚、脱水羌活酚、花椒毒酚、佛手柑亭、７－ｉｓｏｐｅｎｔｅｎｙｌｏｘｙ－６－ｍｅｔｈｏｘｙ－ｃｏｕｍａｒｉｎ和７－（３，７－ｄｉｍｅｔｈｙｌ－２，６－ｏｃｔａｄｉｅｎｙｌｏｘｙ）－６－ｍｅｔｈｏｘｙ－ｃｏｕｍａｒｉｎ以及紫花前胡甙（ＸＶ）。

Three new coumarins were isolated from Notopterygium incisum Ting. On basis ofspectral data(uv,IR,MS,NMR and 2DNMR),they were elucidated to be 5-[(2E-3,7-dimethyl-5-ethoxy-2,6-octadienyloxy]psoralen,named ethylnotopterol ⅩⅡ);5-{(2E, 5E)-3,7-dimethyl-7-[(1-ethoxy)-ethoxy-2,5-octadienyloxy]}psoralen,nam ed notoptolide(ⅩⅢ),and 5-[( 2E)-3,7-dimethyl-5,6-epoxy-2,7-octadienyloxy] psoralen,named anhydronotoptoloxide(ⅩⅣ).Moreover,twelve known coumarins have been isolated and identified as bergapten(Ⅰ),isoimperatorin(Ⅱ),demethylfuropinnaein (Ⅲ),bergaptol(Ⅳ),notopterol(Ⅴ),notoptol(Ⅵ),anhydronotoptol(Ⅶ),xa nthotoxol(Ⅷ),bergamottin(Ⅸ),7-isopentenyloxy-6-methoxy-coumarin(Ⅹ) ,7-(3,7-dimethyl-2,6-octadienyloxy)-6-methoxy-coumarin(Ⅸ) and nodakenin(ⅩⅤ).