摘要
南蛇藤素（Ｃｅｌ）对豚鼠精子前向运动（ＦＭ）、获能（Ｃａｐ）、顶体反应（ＡＲ）和穿透去透明带仓鼠卵（ＳＰＡ）均有明显的抑制作用，其作用强度随剂量而增加；对Ｃｅｌ的敏感性依次为精子Ｃａｐ＞ＦＭ＞ＳＰＡ＞ＡＲ。Ｃｅｌ对豚鼠精子ＡＲ，ＦＭ和Ｃａｐ的抑制作用比乙酸棉酚（ＧＡ）明显为强。
The effects of celastrol(Cel),isolated from
Tripterygium wilfordii,on guinea pigsperm forward
motility(FM),capacitation(Cap),the acrosome reaction(AR)and
spermpenetration assay(SPA)were assessed in vitro.Cel(5 μg·
ml-1)was found to inhibit thesespermatozoal functions,and the
inhibitions were proportional to the concentrations of Cel
used.Thepotency of inhibition of Cel on the fertilizing ability in
guinea pig spermatozoa in vitro seems to followthe order
:Cap>FM>SPA>AR.The inhibitory effect appeared to be reversible after
washing awayCel if the duration of exposure of spermatozoa to Cel was
shorter than 3 h. In a comparative study,the inhibitory effects of
Cel on guinea pig sperm FM and AR were significantly stronger than
those ofgossypol acetic acid.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第5期331-335,共5页
Acta Pharmaceutica Sinica
基金
美国洛氏基金
