摘要
格列吡嗪胶囊的药代动力学及生物利用度研究陈秋潮，杨春芹，赵彩虹，马永贵，李雪宁，陈伟力（上海医科大学中山医院药剂科２０００３２）格列吡嗪（ｇｌｉｐｉｚｉｄｅ，简称Ｇ）属新的磺酰脲类降糖药，主要用于Ⅱ型（非胰岛素依赖型）糖尿病。其药理作用主要是直接刺激...
The pharmacokinetics and
bioavailability of glipizide were studied in 8 healthymaie volunteers
after a single oral dose of 5 mg in capule or in tablet.The plasma
levels of glipizldewere assayed by high performance liquid
chromatography.The concentration time curves of bothpreparations
were fitted to a one compartment model.The pharmacokinetic parameters
of glipizide incapsule and in tablet were shown in tables 2 and 3.The
relative bioavailability of the capsule was109.9%compared with the
tablet.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第6期476-480,共5页
Acta Pharmaceutica Sinica
