摘要
骨质疏松防治药物研究（３）：喹啉酮类衍生物的合成及其抗骨质疏松活性徐鸣夏，段文虎，郑虎（成都华西医科大学药化教研室６１００４１）雌激素可预防和治疗绝经后的骨质疏松症，其中雌二醇最常用。但长期使用雌激素有诱发乳腺癌及子宫内膜癌的危险，因此，需有既具抗骨...
In order to obtain more
effective drugs with less side effects for the treatment
ofosteoporosis ,we designed and synthesized fourteen quinolinone
derivatives.The 14 title compounds have not been reported in
literature.Their structures were confirmed byelemental analysis ,IR ,
MS and 1H-NMR.Initial pharmacological test showed that target
compound TM-11 could stimulate bone formationin Wistar rat embryo in
culture and showed higher activity in stimulating bone formation
thanipriflavone.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第10期792-795,共4页
Acta Pharmaceutica Sinica
